Contact Information

UCLA School of Medicine - Division of Digestive Diseases
Box 951792, VA Greater LA Healthcare System Building 115, Room 118
Los Angeles, CA 90095-1792
On-campus mail: 179247
Tel: (310) 268-3863
Fax:(310) 268-4963
E-mail: mmuluget@ucla.edu

Biosketch

Dr. Million Mulugeta received his DVM from the Addis Ababa University, Faculty of Veterinary Medicine, Ethiopia. He then moved to France and obtained his MVSc and Ph.D in Digestive Physiology/Pharmacology, from the Toulouse National Veterinary School and INRA, Department of Pharmacology and Toxicology, Toulouse France. In 1995, he joined CURE/UCLA, Digestive Diseases Research Center as post-doctoral fellow in the Brain-Gut Interaction laboratories headed by Dr. Taché. Dr. Million is currently an Adjunct Associate Professor and Co-Director of the pre-Clinical Stress Biology Program of Center for Neurovisceral Sciences & Women's Health. Dr Million's major work is related to the mechanisms and signaling pathway of corticotrophin-releasing factor (CRF) and stress on colonic function and visceral pain. Based on his observation on the differential effects of CRF receptor 1 and 2 activation in visceral pain responses, Dr Million's work focuses on understanding the molecular basis and neuronal pathways of the CRF system involved in the visceral pain modulation.

Selected References

Million M, Tache Y, Anton P. Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF. Am J Physiol. 276:G1027-36 (1999).

Million M, Wang L, Martinez V, Tache Y. Differential Fos expression in the paraventricular nucleus of the hypothalamus, sacral parasympathetic nucleus and colonic motor response to water avoidance stress in Fischer and Lewis rats. Brain Res. 877:345-53 (2000).

Kresse AE, Million M, Saperas E, Tache Y. Colitis induces CRF expression in hypothalamic magnocellular neurons and blunts CRF gene response to stress in rats. Am J Physiol Gastrointest Liver Physiol. 281:G1203-13 (2001).

Million M, Grigoriadis DE, Sullivan S, Crowe PD, McRoberts JA, Zhou H, Saunders PR, Maillot C, Mayer EA, Tache Y. A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res. 9851:32-42 (2003).

David W Adelson. and Million M Tracking The Movable Feast: Sonomicrometry and Gastrointestinal motility, NIPS, 19: 27-32 (2004).