Neurobiology of Stress
10945 Le Conte Avenue, Suite 2338, Room F
Los Angeles, CA 90095-6949
Tel: (310) 206-0192
Fax: (310) 206-3343
Dr. Mayer has
a longstanding interest in clinical and neurobiology aspects of
brain-gut interactions in health and disease. He has published more
than 110 original articles, numerous review articles and chapters,
co-edited two books and organized several interdisciplinary symposia
in this area. Dr. Mayer has made seminal contributions to the characterization
of physiologic alterations in patients with functional disorders,
in particular in the area of visceral pain, stress-induced visceral
hyperalgesia and altered brain responses. He has two active R01
grants, one on basic mechanisms of NMDA receptors in visceral nociception,
the other on brain and perceptual responses to visceral stimulation.
He is P.I. on a subcontract of another RO1 grant on the role of
proteinase-activated receptors in neuronal activation, and co-investigator
on a RO1 grant (P.I. Lin Chang) dealing with neuroendocrine alteration
in IBS and fibromyalgia. Dr. Mayer has served on the editorial boards
of the leading journals in digestive diseases, including Gastroenterology,
Gut, Digestion and the American Journal of Physiology. He has served
as reviewer for a wide range of medical and neuroscience journals
and as ad hoc reviewer for national and international funding agencies.
He has also served on ad hoc NIH study sections.
Dr. Mayer has
been involved in an administrative and leadership function in several
large interdisciplinary programs at UCLA. He is the Director of
the UCLA Center for Neurovisceral Sciences & Women's Health
(CNS), a translational research program recently funded by the NIH
that is currently viewed as the leading integrated research program
in the world in the area of functional digestive disorders. Senior
investigators within the CNS perform a wide range of basic and clinical
research activities in the area of neurovisceral interactions in
health and disease. Research efforts of this program include the
study of cellular and molecular mechanisms of chemo- and mechanotransduction
of primary afferent nerves; animal studies on stress modulation
of visceral pain and associated autonomic responses; human physiology
studies on cerebral, autonomic, neuroendocrine, and perceptual responses
to visceral stimulation; and health outcomes, quality of life, and
epidemiological studies in populations suffering from chronic gastrointestinal
disorders. The Center includes more than 15 M.D. and Ph.D. researchers
who are supported by individual RO1 grants. Dr. Mayer is the Chair
of the recently established UCLA Collaborative Centers for Integrative
Medicine, a multidisciplinary and interdepartmental clinical and
research program related to different aspects of integrative medicine.
Dr. Mayer has trained close to 20 postdoctoral fellows and has played
an active role in promoting an integrative model of mind/brain/body
interactions in his clinical practice, lectures and publications.
Along these lines, he has organized two seminal interdisciplinary
symposia on different aspects of mind/brain/body interactions and
has published a volume of Progress in Brain Research on this topic.
Berman S, Chang
L, Suyenobu B, Derbyshire SGW, Fitzgerald L, Mandelkern M, Hamm
L, Vogt B Naliboff BD, Mayer EA. Condition-specific deactivation
of emotional motor system in IBS patients. Gastroenterology. 2002.
McRoberts JA, Ennes HS, Song B, Wang X, Jinton L, Corneliussen B,
Mayer EA. Two N-methyl-D-aspartate receptors in rat dorsal
root ganglia with different subunit composition and localization.
Journal of Comparative Neurology. 2002; 446: 325-341.
Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani
M, Hollenberg MD, Wallace JL, Caughey GH, Mitchell SE, Williams
LM, Geppetti P, Mayer EA, Bunnett NW. Agonists of proteinase-activated
receptor 2 induce inflammation by a neurogenic mechanism. Nature
Medicine. 2000; 6:151-158.