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research has advanced the study of substance abuse and the development
of new approaches and probes for studies of brain function. She
has edited several books and authored over 200 original research
articles and over 60 reviews. Her most recognized accomplishments
involve PET scanning of human subjects who suffer from addictions.
Dr. London's group was the first to show a relationship between
drug craving and activity of brain regions that link memory with
emotion. She also showed that drug abusers have structural abnormalities
in prefrontal cortex and deficits in decision-making tasks that
depend on prefrontal cortex function. Her work influenced other
researchers to look toward the frontal lobe for an understanding
of the compulsive self-administration of drugs despite detrimental
effects, which characterizes drug addiction. Most recently, she
and her colleagues have developed new probes for external imaging
of those receptors in the brain where nicotine binds to produce
its behavioral actions.
Grant S, London
ED, Newlin DB, Villemagne VL, Liu X, Contoreggi C, Phillips
RL, Kimes AS, Margolin A. Activation of memory circuits during cue-elicited
cocaine craving. Proceedings of the National Academy of Science,
USA. 1996; 93:12040-12045.
Newlin DB, Wong
CJ, Stapleton JM, London ED. Intravenous cocaine decreases
cardiac vagal tone, vagal index (derived in Lorenz space), and heart
period complexity (approximate entropy) in cocaine abusers. Neuropsychopharmacology.
Ernst M, Grant S, Bonson K, Weinstein A. Orbitofrontal cortex and
human drug abuse: functional imaging. Cerebral Cortex. 2000; 10:334-342.