Contact Information

University of Southern California
Keck School of Medicine
Dept. of Cell and Neurobiology
1333 San Pablo St., BMT 401, MC 9112
McKibben Annex, MCA-B1
Los Angeles, CA 90089-9112
Tel: (323) 442-1585, (323) 226-7975
Fax: (310) 471-0254
E-mail: holschne@usc.edu

Biosketch

A dilemma in functional neuroimaging is that immobilization of the subject, necessary to avoid movement artifact, extinguishes all but the simplest behaviors. Recently we developed a miniature, implantable microbolus infusion pump (MIP) that allows bolus injection of radiotracers by remote activation in freely-moving, nontethered animals. A central focus of our laboratory has been to apply this pump as a tool for brain mapping fundamental mammalian behaviors (e.g. mating, aggression, social behavior) that have previously not been accessible using conventional neuroimaging methods. Other research in progress includes: (1) The characterization of the abnormalities in serotonergic function, anxiety and altered heart rate dynamics of mice deficient in monoamine oxidase-A and B. This mouse model is being used as a tool for understanding the dysregulation of behavior and autonomic function seen in human anxiety disorders, (2) The development of a minimally invasive method for the measurement of cardiac output in transgenic animals and man using dye dilution and skin fluorescence.

Selected References

Holschneider DP, Scremin OU, Huynh L, Chen K, DeMaeyer E, Seif I, Shih JC, "Regional Cerebral Cortical Activation In MAO-A Deficient Mice: Differential Effects Of Chronic Versus Acute Elevations In Serotonin And Norepinephrine", Neuroscience, 101(4):869-877, 2000.

Holschneider DP, Scremin OU, Chialvo D, Chen K, Shih JC, “Heart Rate Dynamics in Monoamine Oxidase A and B Deficient Mice”, Am J Physiol, Heart & Circ Physiol 282(5):H1751-9, 2002.

Holschneider DP, Maarek J, Harimoto J, Yang J, Scremin OU, “An Implantable Bolus Infusion Pump For Use In Freely Moving, Nontethered Rats”, Am J Physiol, Heart & Circ Physiol, 283(4):H1713-19, 2002.

Holschneider DP, Maarek J, Yang J, Harimoto J, Scremin OU “Functional Brain Mapping in Freely Moving, Nontethered Rats During Treadmill Walking”, J Cerebr Blood Flow Metab, 23(8):925-932, 2003.

Maarek J-M I, Holschneider DP, Scremin OU, Harimoto J, Yang J, Rubinstein E, “Measurement of Cardiac Output with Indocyanine Green Transcutaneous Fluorescence Dilution Technique”, Anesthesiol, in press.