Helena S. Ennes, M.D.

Assistant Researcher, Department of Medicine - Division of Digestive Diseases, at the David Geffen School of Medicine, UCLA, and CNS: Center for Neurovisceral Sciencs & Women's Heal
 

Contact Information

UCLA Department of Medicine, Division of Digestive Disease
900 Veteran Avenue
Room 14-101 Warren Hall
Los Angeles, CA 90095
On-campus mail: 178622
Tel: (310) 825-4786
Fax: (310) 267-4835
E-mail: helennes@ucla.edu


Biosketch

 

Helena Ennes is an Associate Researcher in the Department of Medicine at UCLA
Dr. Ennes has a longterm interest in the neurobiology of the gastrointestinal tract and brain-gut interactions in health and disease.
At the present time her main focus is the study of peripheral NMDA receptors and how they mediate nociceptive responses in the GI tract.
Additional research interests include the study of cellular and molecular mechanisms of chemo- and mechanotransduction by primary afferent nerves and animal studies on stress modulation of visceral pain and associated autonomic responses
She combines an extensive variety of in vivo, in vitro and ex vivo techniques to address these hypothesi

 

Selected References

Ennes HS, Young SH, Raybould HE, Mayer EA. Intercellular communication between dorsal root ganglion cells and colonic smooth muscle cells in vitro. Neuroreport 1997;8:733-73.

Ennes HS, Young SH, Goliger JA, Mayer EA. Chemical signaling from colonic smooth muscle
cells to DRG neurons in culture. Am J Physiol Gastrointest Liver Physiol 1999;276:C602-10.

Ennes HS, McRoberts JA, Hyman PE, Snape WJ Jr. Characterization of colonic circular smooth muscle cells in culture. Am J Physiol Gastrointest Liver Physiol 1992;263:G365-G370.

Marvizon JC, McRoberts JA, Ennes HS, Song B, Wang X, Jinton L, Corneliussen B, Mayer EA. Two N-methyl-D-aspartate receptors in rat dorsal root ganglia with different subunit composition and localization. Journal of Comparative Neurology. 2002; 446: 325-341.

Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani M, Hollenberg MD, Wallace JL, Caughey GH, Mitchell SE, Williams LM, Geppetti P, Mayer EA, Bunnett NW. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 2000;6:151-8.

Bradesi S, Schwetz I, Ennes HS, Lamy CMR, Ohning G, Fanselow M, Pothoulakis C, McRoberts JA, and Mayer EA. Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia.. Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G42-53. Epub 2005 Mar

McRoberts JA, Coutinho S, Marvizón JCG, Grady EF, Tognetto M, Sengupta JN, Ennes HS, Chaban VV, Amadesi S, Creminon C, Lanthorn T, Geppetti P, Bunnett NW, Mayer EA. Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology, 120: 1734-1748, 2001.