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Nigel
Bunnett, M.D. Professor, Department of Surgery and Physiology, UCSF |
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Contact Information Department
of Surgery
The principal objective of my research is to understand the mechanisms of intercellular signaling and signal transduction by neuropeptides, proteases and their G-protein coupled receptors, and to define the contributions of these mediators to inflammatory diseases and pain transmission. I investigate these mechanisms using a reductionist approach at the molecular and cellular level, and by integrative studies using intact animals and experimental models of disease.
Selected References Roosterman
D, Schmidlin F and Bunnett NW. Rab5a and rab11a mediate agonist-induced
trafficking of protease-activated receptor 2. Am J Physiol Cell
Physiol 284: C1319-1329, 2003. Kirkup AJ, Jiang
W, Bunnett NW and Grundy D. Stimulation of the proteinase-activated
receptor 2 excites jejunal afferent nerves in anaesthetized rats.
J Physiol, 2003. Cottrell G,
Amadesi S, Grady EF and Bunnett NW. Trypsin IV: A novel agonist
of protease-activated receptors 2 and 4. J Biol Chem. In press,
2003. Ossovasaka V,
Bunnett NW. Protease-activated receptors: contribution to
physiology and disease. Ann Rev Physiol. In press, 2003. |
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